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cellZscope

The cellZscope is a computer-controlled device that measures the impedance of barrier-forming cell cultures grown on permeable membranes.

Manufacturer: nanoAnalytics GmbH

cellZscope impedance based cell layer analyzer

The cellZscope is a computer-controlled device that measures the impedance of barrier-forming cell cultures grown on permeable membranes.

  • Measures and records the ohmic resistance (TER, transepithelial / -endothelial resistance) and capacitance (Ccl) of the cell layers under investigation 
  • Computer-controlled and therefore allowing automated, long-term monitoring experiments without any intervention. 
  • Three modules are available and these are optimized for use with small ("24-well" type), mid-sized ("12-well" type), or large ("6-well" type) inserts, respectively. 
  • Fully compatible with a broad range of inserts from different manufacturers, e.g. BD Biosciences, Corning, Greiner Bio-One, Millipore, and Nunc. 

A direct correlation exists between the permeability of a cell layer and its electric resistance, the so called transepithelial / -endothelial electric resistance (TER): tight cell layers exhibit high electric resistance and - vice versa - high permeability correlates with low electric resistance. Therefore, the electric resistance measured across a cell layer is a highly qualified parameter for quantifying leak tightness of barrier forming tissue. 

The cellZscope measures and records the TER of barrier forming cells in order to compare and monitor the establishment or modulation of barrier-forming cell-to-cell contacts. During an experiment the cell module is typically placed inside a standard incubator while the external controller is connected to a computer running the cellZscope software. The device is easy to operate and has a broad range of possible applications. In particular, it is ideally suited for studying the influence of substances such as drugs, toxins etc. on the barrier function of cell layers.

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