RASTRUM™ Allegro

Inventia Life Science

High-througput 3D cell models in minutes

Designed to meet the demands for drug discovery and translational research, RASTRUM Allegro provides the reproducibility and scalability you need to advance your research. By streamlining 3D cell model creation, RASTRUM Allegro accelerates your time to results, helping you reach breakthroughs faster and more efficiently.

Key features

Step into the future of 3D biology with the RASTRUM Allegro platform by creating dynamic tissue microenvironments and studying realistic cell behaviors under phenotypically relevant conditions.

With RASTRUM Allegro you have access to:

  • Higher throughput: 35+ plates in 8 hours
  • High precision: post-print CVs <10% even with sensitive cells
  • Increased efficiency: 3.5x more cell models
  • Fast process: 6 min per 96-well plate
  • Intuitive user experience, no coding required
  • Seamless integration of cell models into your existing workflows
  • Drop-on-demand printing technology
  • Off-the-shelve consumables

Sales in

Austria, Belgium, Denmark, Finland, France, Germany, Ireland, Luxembourg, Norway, Slovenia, Sweden, Switzerland, The Netherlands, United Kingdom

Scale your 3D cell culture with the RASTRUM Allegro

The RASTRUM Allegro empowers you to optimise therapeutic strategies and accelerate your path to discovery by streamlining the creation of 3D cell models. You can produce your own 3D cell models in minutes using its drop-on-demand technology and innovative, precision robotics. RASTRUM Allegro delivers the reproducibility you need to generate 3D cell models at scale, supporting screening campaigns and enabling meaningful insights and confident decision-making.

The RASTRUM Allegro supports high-throughput screening by creating a full 3D cell model:

  • In 6 minutes for a 96-well plate
  • In 9 minutes for a 384-well plate
  • In over 35 plates every working day

The platform will:

  • Deliver highly consistent results by minimising variability.
  • Maximise the generation of higher quantities of 3D cell models from every unique sample.
  • Produce 3.5x more models from just a few thousand cells.
  • Make the most of your resources and advance your research efficiently.

RASTRUM Allegro allows researchers to recreate complex tumor and tissue microenvironments and study the dynamic interactions between key tumor cell types, such as cancer, stromal and vascular cells. This advances our understanding of disease mechanisms and therapeutic development. You can create more 3D cell models from each sample, including your most precious patient biopsies.

Preserving 3D integrity – RASTRUM’s inert base layer, which coats the bottom of the well, prevents cells from migrating towards plastic surfaces, where they attach and lose their 3D characteristics. This innovation preserves the integrity of the 3D microenvironment, preventing the formation of 2D monolayers and enabling experiments that are more physiologically relevant. RASTRUM Allegro delivers the reproducibility you need to generate 3D cell models on a large scale, supporting screening campaigns and enabling meaningful insights and confident decision-making.

The RASTRUM platform workflow

The platform enables deep investigation into biologically relevant conditions through engineered 3D architectures. Simply point, click, and experiment using the cloud-based guided experimental design, ready-to-use protocols, and expert assistance. Develop your 3D model from start to finish in 5 steps:

  1. First, select your matrix from a large library of different matrices to mimic your individual tissue microenvironment.
  2. Second, select your model architecture by choosing the structure and cell model that best meet experimental needs.
  3. The third step is to follow a simple protocol to prepare your cells.
  4. In the fourth step, you generate your 3D cell model using RASTRUM’s drop-on-demand bioprinting technology.
  5. The fifth and final step is to grow your cell model and integrate your analysis with existing downstream workflows and readouts.

Different cell model architectures allow you to cover a range of applications, including imaging, screening and cell extraction. These flexible architectures can be seamlessly integrated into various well plate formats, trans-well inserts or cover slips.

Downloads

Getting started with the RASTRUM platform

Learn more about the RASTRUM workflow and get started with the production of 3D cell models.

RASTRUM Allegro. 3D Biology. This time it is different.

Produce 3D cell models in minutes with RASTRUM Allegro, and access the reproducibility, efficiency, and scalability you need.

RASTRUM technology overview

A detailed description of the RASTRUM technology

Technical data

PRINTING SPECIFICATIONS
Minimum drop volume 15 nl
Minimum drop diameter 150 μm
Minimum layer thickness 50 μm
Active printing nozzles 8
Drop placement resolution 20 μm
Maximum print frequency 1,000 drops per second (1,000 Hz)
Typical print frequency 300 drops per second (1,000 Hz)
Substrate SBS-standard micro plates: 24, 96, 384
(custom fixtures on request)
OPERATING ENVIRONMENT
Electrical Input:
Weight 24 VDC
Unit dimensions (D × W × H) 50 kg (110.2 lbs)
Air supply 589.5 x 532.2 x 493 mm
Mini air compressor (optional) 300 kPa (3 bar) max air pressure
Laminar Air Filter 300 kPa (3 bar) max air pressure
Cleaning Medical grade class H14 HEPA filters
Protocol to come
PC & SOFTWARE
Supplied PC Microsoft 11 Windows Pro 64-bit
Connectivity USB-A to USB-B cable
Supported operating system Windows 11