Bioprofile® Flex2

Multi-sensor analysis system

Manufacturer: nova® biomedical

BioProfile® FLEX2 combines a new MicroSensorCard technology with an optional CD/V module to measure up to 16 essential cell culture parameter in just a few minutes. 

This modern configuration comes up with a very low maintenance and the calibration and quality control will be automatical. 

Beside the main module for measuring the metabolites and gases there will be some optional modules available for the cell counting/vialibility and the osmolality.

BioProfile® FLEX2 is able to determine with a high measurement precision in just 4.5 minutes the following cell parameter: 

Gluc, Lac, Gln, Glu, NH4+, Na+, K+, Ca2+, pH, PCO2, PO2, total cell density, viable cell density, viability, cell diameter and osmolality.

Compared to the previous generation the new BioProfile® FLEX2 reduced the sample volume by 75 % to 265 µl. 

The automatic sampling from 96-well plates, manual from syringes or cups or in an external „load-and-go“ tray for 24 positions provide a maximal flexibility and highest efficiency for the control of cell culture. Therefore this system is also ideal for samples from microbioreactors like an AMBR®-System.


The intuitive user interface software provides all features for 21 CFR Part 11 Compliance. BioProfile® FLEX2 correspond to GMP pharmaceutic production.

ModuleAnalysis timeSample size
Gas Module: pH, pCO2, pO2120 sec.265 µl
Chem. Module: Gluc, Lac, Gln, Glu, NH4+, Na+, K+, Ca2+120 sec.135 µl
Osmometry Module: Osmolality230 sec.135 µl
CD/V Module: total cell density, viability, cell diameter240 sec.135 µl
All Modules - All Tests270 sec.265 µl

Options for sampling:

  • Manual (from syringes or cups)
  • 24-Position tray
  • 96-well plate
  • External Sample Modul (ESM) (optional)
  • Autosampler (optional)

Measurement range:


0,1 - 30 g/l
0,1 - 12 g/l
0,1 - 12 mmol/l
0,1 - 12 mmol/l
0,2 - 25 mmol/l

Cell density
Cell diameter

0 - 2000 mOsm/kg
1 x 105 - 8 x 107 Zellen/ml
0 - 100%
4 - 70 µm


40 - 320 mmol/l
1,0 - 100 mmol/l
0,1 - 10,0 mmol/l


5,00 - 8,00
3,0 - 200 mmHg
3,0 - 500 mmHg

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