The ProteinMaker 6-Channel by Protein BioSolutions is an automated chromatography system for parallel purification of up to six independent protein samples. It combines high-throughput capabilities with flexible method development, making it an essential tool for biopharma, antibody production, and process development.

Unlike traditional sequential processing, the ProteinMaker 6-Channel enables simultaneous purification of multiple samples, streamlining workflows and increasing laboratory efficiency. It supports a variety of chromatographic techniques, including affinity chromatography, ion exchange (IEX), hydrophobic interaction (HIC), and immobilized metal affinity chromatography (IMAC), making it a powerful yet cost-effective solution for R&D laboratories, process optimization teams, and academic research groups.

The ProteinMaker 6-Channel integrates an XYZ robotic system to handle elution and collection with minimal (or none) manual intervention. The system has syringe pump-based flow control, ensuring precise and reproducible purification workflows while significantly reducing hands-on time. This walk-away automation allows scientists to focus on data analysis and method development rather than purification setup.

The system is also equipped with built-in UV detectors (280nm & optional 254nm), which provide real-time monitoring of proteins during purification. These detectors allow continuous elution profiles, enabling researchers to identify optimal purification fractions and improve workflow efficiency.

With the flexibility to run six (different) purification methods simultaneously, the PM6 provides an ideal solution for method development and screening applications. Users can explore different chromatography resins, buffer conditions, and purification strategies in a single run.

The PM6 is aimed at small- and medium-scale process development, offering a robust platform for screening chromatography conditions, optimizing purification strategies, and refining workflows. It can handle sample volumes ranging from a few milliliters to over 1 liter, making it adaptable for early-stage research and pilot-scale production.

By enabling parallel purification of multiple protein constructs, antibody variants, or experimental conditions, the ProteinMaker accelerates method development and provides valuable insights into scalability and reproducibility before transitioning to larger-scale purification processes and systems.